Monograph Details
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Urogenital System
> Overactive bladder/enuresis
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DITROPAN XL |
| Manufacturer |
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Ortho-McNeil Pharmaceuticals, Inc. |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Antispasmodic/anticholinergic. |
| Generic Name |
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Oxybutynin chloride 5mg, 10mg, 15mg; ext-rel tabs. |
| Indications |
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Overactive bladder with symptoms of urge urinary incontinence, urgency, and frequency. Neurologic detrusor overactivity symptoms in children. |
| Children |
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<6yrs: not recommended. ≥6yrs: Swallow whole. Take with fluid. Initially 5mg once daily; may increase in 5mg increments; max 20mg/day. |
| Adults |
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Swallow whole. Take with fluid. Initially 5mg or 10mg once daily; may increase weekly in 5mg increments; max 30mg/day. |
| Contraindications |
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Urinary or gastric retention; uncontrolled narrow-angle glaucoma; or patients at risk for these. |
| Precautions |
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Bladder outflow or GI obstruction. Hepatic or renal impairment. Ulcerative colitis. Intestinal atony. Myasthenia gravis. GERD. GI narrowing or stricture. Exposure to high environmental temperatures. Pregnancy (Cat.B). Nursing mothers. |
| Interactions |
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Increased drowsiness with alcohol, other CNS depressants. Additive anticholinergic effects with other anticholinergics. May be potentiated by CYP3A4 inhibitors. Decreases GI motility, possibly affecting absorption of other drugs. Caution with drugs that can cause or exacerbate esophagitis (eg, bisphosphonates). |
| Adverse Reactions |
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Dry mouth, constipation, somnolence, headache, diarrhea, nausea, tachycardia, blurred vision, dry eyes, other anticholinergic effects. |
| How Supplied |
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Tabs—100 |
| Additional Resources |
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• Related Prescribing Note |
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