Monograph Details
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Urogenital System
> Overactive bladder/enuresis
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DITROPAN |
| Manufacturer |
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Ortho-McNeil Pharmaceuticals, Inc. |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Antispasmodic/anticholinergic. |
| Generic Name |
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Oxybutynin chloride 5mg; scored tabs. |
| Also |
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• DITROPAN SYRUP
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| Indications |
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Symptoms of bladder instability associated with voiding in patients with uninhibited neurogenic or reflex neurogenic bladder (eg, urinary urgency, frequency, leakage, urge incontinence, dysuria). |
| Children |
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<5yrs: not recommended. ≥5yrs: 5mg twice daily; max 15mg/day. |
| Adults |
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5mg 2–3 times a day; max 20mg/day. |
| Contraindications |
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Uncontrolled glaucoma. GI obstruction. Paralytic ileus. Intestinal atony in elderly or debilitated. Severe colitis. Myasthenia gravis. Megacolon. Toxic megacolon in ulcerative colitis. Obstructive uropathies. Unstable cardiovascular status in acute hemorrhage. |
| Precautions |
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Activities requiring mental alertness. Diarrhea. Hepatic or renal disease. Autonomic neuropathy. Hyperthyroidism. Cardiovascular disease. Hiatal hernia. GI or GU obstruction. Ulcerative colitis. Exposure to extreme heat. Elderly. Pregnancy (Cat.B). Nursing mothers. |
| Interactions |
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Potentiates drowsiness with alcohol, other CNS depressants. Additive anticholinergic effects with other anticholinergics. May be potentiated by CYP3A4 inhibitors. Decreases GI motility, possibly affecting absorption of other drugs. |
| Adverse Reactions |
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Dry mouth, constipation, somnolence, headache, diarrhea, nausea, tachycardia, blurred vision, dry eyes, other anticholinergic effects. |
| How Supplied |
Tabs—100, 1000
Syrup—pt |
| Additional Resources |
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• Related Prescribing Note |
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