Monograph Details
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Urogenital System
> Miscellaneous urogenital disorders
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ZYLOPRIM |
| Manufacturer |
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Prometheus Labs, Inc. |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Xanthine oxidase inhibitor. |
| Generic Name |
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Allopurinol 100mg, 300mg; scored tabs. |
| Indications |
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Management of recurrent calcium oxalate calculi in hyperuricosurics. Hyperuricosuria and hyperuricemia induced nephropathy due to cancer chemotherapy. |
| Children |
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Usually not recommended. Chemotherapy–induced nephropathy prophylaxis: <6years: 150mg daily. 6–10years: 300mg daily. |
| Adults |
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Take with food. Calculi: 200–300mg daily. Adjust based on urinary urate levels. Chemotherapy-induced nephropathy prophylaxis: 600–800mg daily for 2–3 days with fluids. |
| Precautions |
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Discontinue if rash occurs. Use only if daily uric acid excretion exceeds 800mg in males or 750mg in females. Advise reduction of animal protein, sodium, refined sugars, oxalate-rich foods, and excessive calcium intake. Increase fiber intake. Renal or hepatic dysfunction. Monitor blood, renal, and hepatic tests for first few months of therapy. Maintain neutral or alkaline urine and increase urine output to ≥2 liters daily. Pregnancy (Cat.C). Nursing mothers. |
| Interactions |
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Increase in azathioprine and mercaptopurine toxicity. May potentiate oral anticoagulants, chlorpropamide, cyclosporine. Uricosurics reduce drug effect. Increased rash with ampicillin, amoxicillin. Monitor renal function with thiazides. |
| Adverse Reactions |
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Rash, GI disorders, acute gout, ecchymosis, fever, headache, hepatic necrosis, drowsiness, neuritis, arthralgia, necrotizing angiitis, blood dyscrasias, bone marrow depression, toxic skin reactions (eg, Stevens-Johnson syndrome), renal failure. |
| How Supplied |
100mg—100
300mg—100, 500 |
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