Monograph Details
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Urogenital System
> Miscellaneous urogenital disorders
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ALOPRIM |
| Manufacturer |
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Nabi |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Xanthine oxidase inhibitor. |
| Generic Name |
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Allopurinol (as sodium) 500mg/vial; pwd for IV infusion after reconstitution and dilution; preservative-free. |
| Indications |
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Chemotherapy-induced hyperuricemia and hyperuricosuria when oral therapy not feasible. |
| Children |
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Give by IV infusion in single or divided doses. Start 1–2 days before chemotherapy. Adjust based on serum uric acid levels. Initially 200mg/m2 per day. Renal impairment: CrCl 10–20mL/min: 200mg/day; CrCl 3–10mL/min: 100mg/day; CrCl <3mL/min: 100mg/day and extend dosing interval; see literature. |
| Adults |
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Give by IV infusion in single or divided doses. Start 1–2 days before chemotherapy. Adjust based on serum uric acid levels. Initially 200–400mg/m2 per day; max 600mg/day. Renal impairment: CrCl 10–20mL/min: 200mg/day; 3–10mL/min: 100mg/dose. <3mL/min: 100mg/day and extend dosing interval (see literature). |
| Contraindications |
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Asymptomatic hyperuricemia. |
| Precautions |
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Maintain adequate hydration (urine output at least 2L/day in adults) and urine alkalinization. Discontinue if rash occurs. Monitor blood counts, renal, and hepatic function for first few months of therapy. Elderly. Pregnancy (Cat.C). Nursing mothers. |
| Interactions |
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Potentiates oral anticoagulants, hypoglycemics, cyclosporine, theophylline. Antagonized by uricosurics. Monitor renal function with thiazides. Reduce concomitant azathioprine, mercaptopurine doses. |
| Adverse Reactions |
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Rash, GI disorders, acute gout, ecchymosis, fever, headache, hepatic necrosis, drowsiness, neuritis, arthralgia, blood dyscrasias, toxic skin reactions, renal failure. |
| How Supplied |
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Vial—1 |
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