Monograph Details
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Urogenital System
> Erectile dysfunction
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MUSE |
| Manufacturer |
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Vivus, Inc. |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Prostaglandin. |
| Generic Name |
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Alprostadil 125micrograms, 250micrograms, 500micrograms, 1000micrograms; urethral suppository. |
| Indications |
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Erectile dysfunction. |
| Children |
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Not recommended. |
| Adults |
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Supervise titration. Initially 125–250micrograms inserted in urethra after urination; adjust dose in stepwise manner on separate occasions; max 2 supps/day. |
| Contraindications |
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Urethral stricture. Balanitis. Severe hypospadias and curvature. Acute or chronic urethritis. Predisposition to venous thrombosis (eg, sickle cell anemia or trait). Hyperviscosity syndrome. Patients for whom sexual activity is inadvisable or contraindicated. If partner is pregnant, use condom; if partner is of childbearing age, use contraception. |
| Precautions |
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Exclude reversible causes. Hypotension. Bleeding disorders. Priapism. Pregnancy (Cat.C): see Contraindications. |
| Interactions |
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Effect attenuated by drugs that interfere with erectile function (eg, decongestants). Caution with anticoagulants. |
| Adverse Reactions |
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Penile, urethral, or testicular pain, urethral burning, minor urethral bleeding/spotting, dizziness, hypotension, flu symptoms, rhinitis, others. Infrequent: priapism. Partners: vaginal burning/itching. |
| How Supplied |
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Urethral supps—6 |
| Additional Resources |
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• Related Prescribing Note |
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