Monograph Details
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Respiratory Tract
> Asthma/COPD
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SINGULAIR ORAL GRANULES |
| Manufacturer |
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Merck & Co., Inc. |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Leukotriene receptor antagonist. |
| Generic Name |
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Montelukast (as sodium) 4mg; per packet. |
| Also |
• SINGULAIR
• SINGULAIR CHEWABLE
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| Indications |
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Prophylaxis and chronic treatment of asthma (for patients ≥12 months old). Prevention of exercise-induced bronchoconstriction (EIB) (for patients ≥15yrs old). |
| Adults and Children |
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Take granules by mouth within 15 minutes of opening packet; may dissolve in 5mL of cold or room temperature baby formula or breast milk, or mix in spoonful of soft applesauce, carrots, rice, or ice cream. <12months: not recommended. 12–23months: one 4mg granule packet. 2–5yrs: one 4mg chew tab or granule packet. 6–14yrs: 5mg chew tab. ≥15yrs: 10mg. For asthma: take once daily in the PM. For EIB: Take at least 2 hours before exercise (max 1 dose/day). |
| Precautions |
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Not for primary treatment of acute attack. Caution when withdrawing from oral steroids. Pregnancy (Cat.B). Nursing mothers. |
| Interactions |
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Monitor with potent CYP450 inducers (eg, phenobarbital, rifampin). Caution with drugs metabolized by CYP2C8 (eg, paclitaxel, rosiglitazone, repaglinide). |
| Adverse Reactions |
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Adults: headache, fatigue, fever, GI upset. Children: also flu/cold symptoms, ear or leg pain, thirst, urticaria. |
| How Supplied |
Tabs, chew tabs—30, 90
Oral granules—30 |
| Additional Resources |
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• Related Prescribing Note |
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