Monograph Details
|
|
Respiratory Tract
> Asthma/COPD
|
|
SEREVENT DISKUS |
| Manufacturer |
|
GlaxoSmithKline Pharmaceuticals |
| Legal Classification |
|
Rx
|
| Pharmacological Class |
|
Long-acting β2-agonist. |
| Generic Name |
|
Salmeterol (as xinafoate) 50micrograms/inh; dry pwd for inhalation; device with drug in blisters. |
| Indications |
|
As an adjunct (see literature): For the maintenance treatment of asthma and in the prevention of bronchospasm in reversible obstructive airway disease (including nocturnal asthma). Maintenance treatment of COPD-associated bronchospasm. Prevention of exercise-induced bronchospasm (EIB). |
| Adults and Children |
|
<4yrs: not recommended. ≥4yrs: 1 inh every 12 hours. EIB prevention: 1 inh at least 30 minutes before exercise. Max 2 doses/day. |
| Contraindications |
|
Not for treatment of acute attacks, or when occasional use of short-acting drugs suffices. Do not initiate in significantly worsening or acutely deteriorating asthma. Salmeterol is not a substitute for steroids. Do not exceed recommended dose. Do not use additional doses for EIB if already using regular dosing for asthma. |
| Precautions |
|
Not for use with other long-acting β2-agonists. Cardiovascular disease (esp. coronary insufficiency, arrhythmias, hypertension). Convulsive disorders. Thyrotoxicosis. Hyperresponsiveness to sympathomimetics. Diabetes. Ketoacidosis. Evaluate response before altering steroid doses. Prescribe an additional short-acting, inhaled β2-agonist for acute symptoms; monitor for increased need. Do not use with spacers. Labor & delivery. Pregnancy (Cat.C). Nursing mothers: not recommended. |
| Interactions |
|
Avoid during or within 2 weeks of MAOIs or tricyclic antidepressants (increased cardiovascular effects). Antagonized by β-blockers. Caution with potassium-depleting diuretics. |
| Adverse Reactions |
|
Hypertension, nasal/sinus congestion, pallor, rhinitis, headache, asthma, tracheitis/bronchitis, otic effects, influenza, transient hypokalemia, muscle cramps, dizziness, paradoxical bronchospasm (esp. with 1st dose of container), immediate allergic reactions, laryngeal spasm, irritation, swelling; rarely: serious asthma episode, asthma-related death. |
| How Supplied |
|
Diskus (w. 60 blisters)—1 |
| Additional Resources |
|
• Related Prescribing Note |
|
|
|
|
