Monograph Details
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Respiratory Tract
> Asthma/COPD
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PERFOROMIST |
| Manufacturer |
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DEY Pharma |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Long-acting β2-agonist. |
| Generic Name |
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Formoterol (as fumarate) 20mcg/2mL; soln for inh. |
| Indications |
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Long-term maintenance treatment of COPD-associated bronchoconstriction. |
| Children |
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Not recommended. |
| Adults |
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20micrograms (1 vial) by nebulizer twice daily (AM & PM). Use standard jet nebulizer (eg, PARI-LC Plus [with face-mask or mouthpiece]) and air compressor (eg, Proneb Ultra compressor). Does not need to be diluted before nebulization. Do not mix with other drugs. |
| Contraindications |
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Not for the treatment of acute attacks or asthma. Do not initiate in significantly worsening or acutely deteriorating COPD. Concomitant use with other long-acting β2-agonists. |
| Precautions |
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Do not exceed recommended dose. Cardiovascular disease (eg, coronary insufficiency, arrhythmias, hypertension). Convulsive disorders. Thyrotoxicosis. Hyperresponsiveness to sympathomimetics. Hypokalemia. Diabetes. Ketoacidosis. Prescribe a short-acting β2-agonist for acute symptoms; monitor for increased need. Pregnancy (Cat.C). Labor & delivery. Nursing mothers. |
| Interactions |
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See Contraindications. Caution with MAOIs, tricyclics, others that prolong QTc interval (may cause ventricular arrhythmias). Antagonized by β-blockers. K+-depleting diuretics, xanthines, steroids may potentiate hypokalemia. Caution with other adrenergics. |
| Adverse Reactions |
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GI upset, nasopharyngitis, dry mouth, dizziness, insomnia; ECG changes or cardiovascular effects (eg, increased BP, tachycardia; consider discontinuing if occur); hypokalemia, hyperglycemia, metabolic acidosis; rarely: paradoxical bronchospasm, increased risk of asthma-related death. |
| How Supplied |
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Single-use vials (2mL)—60 |
| Additional Resources |
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• Related Prescribing Note |
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