Monograph Details
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Respiratory Tract
> Asthma/COPD
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DUONEB |
| Manufacturer |
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DEY Pharma |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Anticholinergic + β2-agonist. |
| Generic Name |
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Ipratropium bromide 0.5 mg/3 mL (0.017%), albuterol (as sulfate) 2.5 mg/3 mL (0.083%); soln for inh. |
| Indications |
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COPD when a second aerosol bronchodilator is needed. |
| Children |
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<18 years: not recommended. |
| Adults |
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≥18 years: 1 vial by nebulizer 4–6 times daily. |
| Contraindications |
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Atropine allergy. |
| Precautions |
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Not for primary treatment of acute attack. Avoid excessive use. Discontinue if paradoxical bronchospasm or cardiovascular effects occur. Cardiovascular disease (eg, coronary insufficiency, arrhythmias, hypertension). Hyperthyroidism. Diabetes. Seizure disorders. Narrow angle glaucoma. GI or GU obstruction. Hepatic or renal disease. Avoid eyes. Pregnancy (Cat.C). Labor & delivery. Nursing mothers: not recommended. |
| Interactions |
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Avoid MAOIs, tricyclics within 14 days (increased cardiovascular effects). Caution with other anticholinergics, sympathomimetics, drugs that lower potassium. Monitor digoxin. Antagonized by β-blockers. |
| Adverse Reactions |
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Lung disorders, pharyngitis, chest pain, GI disturbances, bronchitis, UTI, leg cramps, pain, voice changes, anticholinergic effects, nervousness, headache, dizziness, insomnia, tachycardia, hypokalemia, paradoxical bronchospasm. |
| How Supplied |
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Vials (3 mL)—25 |
| Additional Resources |
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• Related Prescribing Note |
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