Monograph Details
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Respiratory Tract
> Asthma/COPD
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COMBIVENT |
| Manufacturer |
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Boehringer Ingelheim Pharmaceuticals |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Anticholinergic + β2-agonist. |
| Generic Name |
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Ipratropium bromide 18 micrograms, albuterol (as sulfate) 90 micrograms; per inh; metered dose inhaler. |
| Indications |
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COPD when a second aerosol bronchodilator is needed. |
| Children |
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Not recommended. |
| Adults |
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2 inh 4 times daily; max 12 inh/day. |
| Contraindications |
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Atropine, soybean, soya lecithin, peanut, or related allergy. |
| Precautions |
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Avoid excessive use. Cardiac disease and arrhythmias. Hypertension. Diabetes. Hyperthyroidism. Seizure disorders. Narrow angle glaucoma. GI or GU obstruction. Hepatic or renal disease. Pregnancy (Cat.C). Labor & delivery. Nursing mothers: not recommended. |
| Interactions |
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Extreme caution within 2 weeks of MAOIs or tricyclic antidepressants (increased cardiovascular effects). Caution with other anticholinergics, sympathomimetics, drugs that lower serum potassium. Antagonized by β-blockers. |
| Adverse Reactions |
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Bronchitis, upper respiratory tract infection, headache, dyspnea, respiratory disorder, cough, nausea, pain, sinusitis, pharyngitis, influenza, pneumonia, rhinitis, hypertension, dizziness, arrhythmias, nervousness, paradoxical bronchospasm, anaphylaxis. |
| How Supplied |
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Inhaler—14.7 g (200 inh) |
| Additional Resources |
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• Related Prescribing Note |
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