Monograph Details
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Respiratory Tract
> Asthma/COPD
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ASMANEX TWISTHALER |
| Manufacturer |
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Schering Corporation |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Steroid. |
| Generic Name |
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Mometasone furoate 110micrograms/inh, 220micrograms/inh; pwd for oral inhalation, metered-dose inhaler. |
| Indications |
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Maintenance treatment of asthma as prophylactic therapy. |
| Children |
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<4yrs: not recommended. 4–11yrs: 110mcg once in the PM; max 110mcg daily. Rinse mouth after use. |
| Adults |
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Previously on bronchodilators alone or inhaled corticosteroids: initially 220mcg once in the PM; max 440mcg daily (either as 220mcg twice daily or 440mcg once daily). Previously on oral corticosteroids (wean gradually): initially 440mcg twice daily; max 880mcg daily. Rinse mouth after use. |
| Contraindications |
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Not for treatment of acute attacks. Milk protein allergy. |
| Precautions |
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Maintain regular regimen. Infections. If exposed to chickenpox or measles, consider anti-infective prophylactic therapy. Monitor intraocular pressure; bone mineral density if other osteoporosis risk factors exist; and for growth suppression in children; hypercorticism and HPA axis suppression (if occurs, discontinue gradually). If adrenal insufficiency exists following systemic corticosteroids, replacement with inhaled steroids may exacerbate symptoms of adrenal insufficiency (eg, lassitude). Prescribe a short-acting, inhaled β2-agonist for acute symptoms; monitor for increased need. Pregnancy (Cat. C). Nursing mothers. |
| Interactions |
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Caution with potent CYP3A4 inhibitors (eg, ketoconazole). |
| Adverse Reactions |
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Headache, respiratory or other infection, oral candidiasis, dysmenorrhea, musculoskeletal pain, GI upset, allergic rhinitis, sinus congestion, sinusitis, depression, fatigue, pain, bronchospasm (discontinue if occurs). Children: fever, bruise. |
| How Supplied |
Twisthaler 110mcg (30 inh)—1
220mcg (30 inh, 60 inh, 120 inh)—1 |
| Additional Resources |
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• Related Prescribing Note |
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