Monograph Details
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Respiratory Tract
> Asthma/COPD
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ACCOLATE |
| Manufacturer |
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AstraZeneca Pharmaceuticals |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Leukotriene receptor antagonist. |
| Generic Name |
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Zafirlukast 10mg, 20mg; tabs. |
| Indications |
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Prophylaxis and chronic treatment of asthma. |
| Children |
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Take 1 hour before or 2 hours after meals. <5 years: not recommended. 5–11years: 10mg twice daily. |
| Adults |
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Take 1 hour before or 2 hours after meals. 20mg twice daily. |
| Precautions |
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Not for primary treatment of acute attack. Discontinue if clinical symptoms of liver dysfunction occur; do not resume if confirmed by lab results. Caution when withdrawing from oral steroids. Elderly. Pregnancy (Cat.B). Nursing mothers: not recommended. |
| Interactions |
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Potentiates warfarin (monitor PT and adjust warfarin dose). Caution with drugs metabolized by CYP2C9 (eg, tolbutamide, phenytoin, carbamazepine) or CYP3A4 (eg, dihydropyridine calcium channel blockers, cyclosporine, cisapride). Zafirlukast plasma levels reduced by erythromycin, theophylline. Zafirlukast plasma levels increased by aspirin. May increase theophylline levels. |
| Adverse Reactions |
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Headache, infection, GI upset, pain, fever; rarely, hepatic dysfunction (esp. in females), agranulocytosis. |
| How Supplied |
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Tabs—60 |
| Additional Resources |
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• Related Prescribing Note |
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