Monograph Details
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Poisoning & Drug Dependence
> Poisoning/overdose
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NARCAN |
| Manufacturer |
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Endo Pharmaceuticals |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Narcotic antagonist. |
| Generic Name |
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Naloxone 0.02mg/mL, 0.4mg/mL, 1mg/mL; IV, IM or SC inj; amps (paraben-free); vials. |
| Indications |
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Reversal of narcotic depression, including respiratory. Diagnosis of acute opioid overdose. |
| Children |
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See literature. Post-op: 0.005–0.01mg/kg IV, IM or SC, repeat 2–3 minutes until desired response. Overdose: 0.01mg/kg initially; inadequate response 0.1mg/kg body weight. Neonates, post-op: 0.01mg/kg, repeat 2–3 minutes until desired response. |
| Adults |
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See literature. Post-op: 0.1–0.2mg IV, IM or SC, repeat 2–3 minutes until desired response. Overdose: 0.4–2mg IV, IM or SC, repeat 2–3 minutes; if no response after 10mg reevaluate. Both may require repeated doses depending on duration of narcotic activity. |
| Precautions |
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Possible acute abstinence syndrome. Monitor patients with satisfactory response due to long duration of some narcotics. Post-op use in cardiac disease. Pregnancy (Cat.B). Nursing mothers. |
| Interactions |
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Caution with cardiotoxic drugs. Incomplete reversal of buprenorphine. |
| Adverse Reactions |
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Reversal of narcotic depression: nausea, vomiting, sweating, tachycardia, increase blood pressure, tremulousness, seizures, cardiac arrest. Post-op reversal of analgesia and excitement. |
| How Supplied |
Amps 0.02mg, 1mg (2mL)—10
0.4mg (1mL)—10
Vials 0.4mg, 1mg (10mL)—1 |
| Additional Resources |
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• Related Prescribing Note |
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