Monograph Details
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Poisoning & Drug Dependence
> Poisoning/overdose
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DESFERAL |
| Manufacturer |
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Novartis Pharmaceuticals Corp |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Iron chelating agent. |
| Generic Name |
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Deferoxamine mesylate 250mg/mL; for inj after reconstitution. |
| Indications |
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Acute iron intoxication. Chronic iron overload due to multiple transfusions. |
| Adults and Children |
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Routes other than IM: see literature. <3 yrs: not recommended. ≥3 yrs: acute iron toxicity: 1g IM initially followed by 500mg every 4 hours for 2 doses; repeat every 4–12 hours if needed; max 6g/day. |
| Contraindications |
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Severe renal disease. Anuria. |
| Precautions |
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Ocular or auditory disturbances. High doses in patients with low ferritin levels may retard growth. Acute respiratory distress syndrome with high doses. Flushing, urticaria, hypotension, and shock if rapid IV. Discoloration of urine. Pregnancy (Cat.C). Nursing mothers. |
| Adverse Reactions |
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Localized skin reactions, hypersensitivity, tachycardia, hypotension, shock, dysuria, leg cramps, fever, GI upset. |
| How Supplied |
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Vials (500mg)—4 |
| Additional Resources |
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• Related Prescribing Note |
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