Monograph Details
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Poisoning & Drug Dependence
> Poisoning/overdose
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ACETADOTE |
| Manufacturer |
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Cumberland Pharmaceuticals, Inc. |
| Legal Classification |
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Rx
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| Generic Name |
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Acetylcysteine 200mg/mL; soln for IV infusion after dilution; preservative-free. |
| Indications |
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To minimize hepatic injury after acetaminophen overdose. |
| Adults and Children |
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See literature. Obtain serum acetaminophen level 4–12 hours post-ingestion and plot on nomogram; give as soon as possible if serum levels are above treatment level (for immediate-release acetaminophen formulations, give within 8 hours of overdose or ≤24 hours if time of overdose is unknown). Dilute in D5W and give by IV infusion. Loading dose: 150mg/kg given over 60 minutes. Maintenance: 50mg/kg given over 4 hours, then 100mg/kg given over 16 hours. Fluid restriction or <40kg: adjust total volume given. |
| Precautions |
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Asthma. History of bronchospasm. Monitor for severe anaphylactoid reactions; may treat with antihistamines and epinephrine; interrupt or discontinue treatment if persistent. Monitor liver enzymes, creatinine, BUN, electrolytes. Hepatic or renal impairment: see literature. Pregnancy (Cat.B). Nursing mothers. |
| Adverse Reactions |
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Allergic reactions (eg, rash, urticaria, pruritus, angioedema, tachycardia, hypotension, vasodilation, syncope, bronchospasm), GI upset. |
| How Supplied |
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Single-use vial (30mL)—4 |
| Additional Resources |
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• Related Prescribing Note |
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