Monograph Details
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Pain & Pyrexia
> Narcotic analgesics
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ZYDONE 5mg/400mg |
| Manufacturer |
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Endo Pharmaceuticals |
| Legal Classification |
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CIII |
| Pharmacological Class |
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Opioid + analgesic. |
| Generic Name |
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Hydrocodone bitartrate 5mg, acetaminophen 400mg; tabs. |
| Also |
• ZYDONE 10mg/400mg
• ZYDONE 7.5mg/400mg
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| Indications |
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Moderate to moderately severe pain. |
| Children |
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Not recommended. |
| Adults |
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1–2 tabs every 4–6 hrs as needed; max 8 tabs/day. |
| Precautions |
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Head injury. Increased intracranial pressure. Acute abdomen. Impaired pulmonary, renal, hepatic, thyroid, or adrenocortical function. GI or GU obstruction. Drug abusers. Elderly. Debilitated. Labor & delivery. Pregnancy (Cat.C). Nursing mothers: not recommended. |
| Interactions |
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Potentiation with alcohol, antihistamines, other CNS depressants, MAOIs, tricyclic antidepressants, anticholinergics. |
| Adverse Reactions |
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CNS/respiratory depression, GI upset, constipation, urinary retention, rash; hepatotoxicity (overdose). |
| How Supplied |
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Tabs—100, 500 |
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