Monograph Details
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Pain & Pyrexia
> Narcotic analgesics
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OXYCONTIN |
| Manufacturer |
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Purdue Pharma L.P. |
| Legal Classification |
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CII |
| Pharmacological Class |
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Opioid. |
| Generic Name |
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Oxycodone HCl 10mg, 15mg, 20mg, 30mg, 40mg, 60mg, 80mg; controlled-release tabs. |
| Indications |
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Moderate to severe pain when continuous opioid analgesia is needed for extended time period. Not for as-needed use. |
| Children |
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<18 years: not recommended. |
| Adults |
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See literature. Swallow whole. ≥18 years: individualize; usually given on a 12-hour schedule. Opioid-naive: initially 10mg every 12 hours. Converting from other opioids or combinations: see literature. Hepatic dysfunction or concomitant CNS depressants: reduce dose by 1/3 to 1/2. Use 60mg (and higher) strength, or a single dose >40mg, in opioid-tolerant patients only. |
| Contraindications |
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Severe respiratory depression. Acute or severe asthma or hypercarbia. Paralytic ileus. |
| Precautions |
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Not for post-op use unless previously on OxyContin, or if pain expected to be persistent. Head injury. Increased intracranial pressure. CNS depression. Coma. Toxic psychosis. Convulsive disorders. Shock. Impaired pulmonary, renal, hepatic, thyroid, or adrenocortical function. GI or GU obstruction. Acute abdomen. Biliary tract disease. Acute pancreatitis. Volume depleted. Kyphoscoliosis (associated with respiratory depression). Acute alcoholism. Delirium tremens. Avoid abrupt cessation. Reevaluate periodically. Elderly. Debilitated. Pregnancy (Cat.B). Labor & delivery, nursing mothers: not recommended. |
| Interactions |
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Potentiation with alcohol, other CNS depressants, anticholinergics, MAOIs, tricyclic antidepressants, phenothiazines, general anesthetics, skeletal muscle relaxants. |
| Adverse Reactions |
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Somnolence, constipation, nausea, vomiting, dizziness, pruritus, headache, dry mouth, sweating, asthenia, respiratory depression/arrest, hypotension. |
| How Supplied |
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Tabs—100 |
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