Monograph Details
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Pain & Pyrexia
> Narcotic analgesics
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OPANA ER |
| Manufacturer |
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Endo Pharmaceuticals |
| Legal Classification |
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CII |
| Pharmacological Class |
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Opioid. |
| Generic Name |
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Oxymorphone HCl 5mg, 7.5mg, 10mg, 15mg, 20mg, 30mg, 40mg; ext-rel tabs. |
| Also |
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• OPANA
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| Indications |
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Moderate to severe pain when the use of a continuous, around-the-clock opioid is required for an extended period of time. Not for "as-needed" use. |
| Children |
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<18yrs: not recommended. |
| Adults |
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Individualize. Take on empty stomach. May give Opana as needed on an every 4–6 hrs schedule; Opana ER is given on a continuous basis every 12hrs. ≥18yrs: Opioid-naive: Opana: 5–20mg every 4–6 hrs as needed. Opana ER: Swallow whole; 5mg every 12 hrs, titrate by 5–10mg every 12 hours every 3–7 days; titrate to mild or no pain with regular use of up to 2 doses of supplemental (rescue) analgesia per 24hrs. Converting from Opana to Opana ER: Give half the total daily Opana dose as Opana ER every 12 hrs. Converting from parenteral oxymorphone, or other opioids to Opana or Opana ER: see literature. May use concomitant acetaminophen or NSAIDs. Concomitant other CNS depressants: reduce initial dose by ⅓ to ½. Mild hepatic dysfunction, or renal dysfunction (CrCl <50mL/min): reduce initial dose, titrate slowly. |
| Contraindications |
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Moderate to severe hepatic dysfunction. Concomitant alcohol (may cause fatal overdose). Respiratory depression. Acute/severe bronchial asthma. Hypercarbia. Paralytic ileus. |
| Precautions |
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Head injury. Increased intracranial pressure. CNS depression. Coma. Toxic psychosis. Convulsive disorders. Shock. Impaired cardiovascular, pulmonary, hepatic, renal, thyroid, or adrenocortical function. GI or GU obstruction. Acute abdomen. Biliary tract disease. Acute pancreatitis. Volume depleted. Kyphoscoliosis. Acute alcoholism. Delirium tremens. Avoid abrupt cessation. Re-evaluate periodically. Elderly. Debilitated. Pregnancy (Cat.C). Labor & delivery, nursing mothers: not recommended. |
| Interactions |
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Potentiates CNS depression with benzodiazepines, barbiturates, alcohol, other CNS depressants and other psychoactive substances (avoid). Potentiates anticholinergics. Caution with MAOIs. |
| Adverse Reactions |
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Constipation, GI upset, pyrexia, somnolence, dizziness, headache, pruritus, dry mouth, confusion, hypotension; CNS and respiratory depression. |
| How Supplied |
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Tabs—100 |
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