Monograph Details
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Pain & Pyrexia
> Narcotic analgesics
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DEPODUR |
| Manufacturer |
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Endo Pharmaceuticals |
| Legal Classification |
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CII |
| Pharmacological Class |
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Opioid. |
| Generic Name |
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Morphine sulfate 10mg/mL; ext-rel liposomal susp for epidural inj; preservative free. |
| Indications |
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Post-op pain after major surgery. |
| Children |
<18 yrs: not recommended.
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| Adults |
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≥18yrs: Give as a single dose by lumbar epidural inj only, before surgery or after clamping umbilical cord in caesarean section. Individualize. Monitor closely for at least 48 hrs after dosing. Orthopedic surgery (lower extremities): 15mg. Lower abdominal or pelvic surgery: 10–15mg. Caesarean section: 10mg. All: max 20mg. |
| Contraindications |
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Head injury. Increased intracranial pressure. Respiratory depression. Asthma. Upper airway or GI obstruction. Paralytic ileus. Circulatory shock. During or within 14 days of MAOIs. |
| Precautions |
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Conditions that increase risk of respiratory depression (eg, hypercapnia, obesity, surgery cancellation). Impaired myocardial function. Volume depletion. Biliary tract disease. Acute pancreatitis. Seizure disorders. GU obstruction. Drug abusers. Elderly. Debilitated. Labor & delivery (not for use in vaginal delivery). Pregnancy (Cat.C). Nursing mothers. |
| Interactions |
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Epidural local anesthetics (allow at least 15 minutes between test dose and DepoDur inj). Suspend use of other epidural drugs for at least 48 hrs. Potentiated by other CNS depressants (eg, alcohol, other opiates, general anesthetics, sedatives, antihistamines, phenothiazines). Potentiates neuromuscular blockers. |
| Adverse Reactions |
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CNS and respiratory depression, orthostatic hypotension, urinary retention, GI upset, constipation, paralytic ileus, pruritus, biliary colic, bladder spasm, bradycardia, tachycardia, back pain. |
| Extra Text |
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Note: Be fully experienced in the administration of epidural drugs. Have resuscitative equipment and narcotic antagonists immediately available. |
| How Supplied |
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Single-use vials (1mL, 1.5mL, 2mL)—5 |
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