Monograph Details
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Pain & Pyrexia
> Migraine and headache
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Timolol maleate |
| Manufacturer |
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Various generic manufacturers |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Noncardioselective β-blocker. |
| Generic Name |
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Timolol maleate 5mg, 10mg+, 20mg+; tabs; +scored. |
| Indications |
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Migraine prophylaxis. |
| Children |
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Not recommended. |
| Adults |
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Initially 10mg twice a day. Increase weekly if needed; max 30mg daily in 2 divided doses. Evaluate at 6–8 wks. |
| Contraindications |
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Asthma. Severe COPD. Sinus bradycardia. 2nd- or 3rd-degree AV block. Overt heart failure. Cardiogenic shock. |
| Precautions |
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CHF. Ischemic heart disease. Bronchospastic disease, COPD. Renal or hepatic dysfunction. Diabetes. Hyperthyroidism. Cerebrovascular insufficiency. Surgery. SLE. Avoid abrupt cessation. Pregnancy (Cat.C). Nursing mothers: not recommended. |
| Interactions |
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Hypotension, bradycardia with catecholamine-depleting drugs. May increase cardiac effects of calcium channel blockers, digitalis. May be potentiated by quinidine. Increased rebound hypertension with clonidine withdrawal. Antagonized by NSAIDs. Adjust antidiabetic medications. May interfere with glaucoma screening tests. May block epinephrine. |
| Adverse Reactions |
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Cardiac failure, bronchospasm, asthenia, bradycardia, dizziness, arrhythmia, heart block, dyspnea, muscle weakness, cold extremities, depression, decreased libido, chest pain, syncope, pruritus. |
| How Supplied |
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Contact supplier. |
| Additional Resources |
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• Related Prescribing Note |
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