Monograph Details
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Pain & Pyrexia
> Migraine and headache
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RELPAX |
| Manufacturer |
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Pfizer Labs |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Selective 5-HT1B/1D receptor agonist. |
| Generic Name |
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Eletriptan (as HBr) 20mg, 40mg; tabs. |
| Indications |
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Acute treatment of migraine. |
| Children |
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<18yrs: not recommended. |
| Adults |
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≥18yrs: 20mg or 40mg once. Reevaluate if no response. May repeat once after 2 hours; max 80mg/day. The safety of treating an average of more than 3 headaches in a 30-day period has not been established. |
| Contraindications |
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Ischemic heart or cerebrovascular disease (eg, angina, TIA). Peripheral vascular disease (eg, ischemic bowel disease, Raynaud's syndrome). Uncontrolled hypertension. Other significant cardiovascular disease. Severe hepatic dysfunction. Basilar or hemiplegic migraine. Within 24 hours of ergots or other 5-HT1 agonists. Within 72 hours of potent CYP3A4 inhibitors (eg, ketoconazole, itraconazole, nefazodone, troleandomycin, clarithromycin, ritonavir, nelfinavir). |
| Precautions |
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Confirm diagnosis. Exclude underlying cardiovascular disease, supervise 1st dose, and consider monitoring ECG in patients with likelihood of unrecognized coronary disease (eg, post-menopausal women, men over age 40, hypertension, hypercholesterolemia, obesity, diabetes, smokers, strong family history). Elderly. Pregnancy (Cat.C). Nursing mothers. |
| Interactions |
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Ergotamines, other 5-HT1 agonists, or potent CYP3A4 inhibitors: see Contraindications. Serotonin syndrome with SSRIs (eg, fluoxetine, fluvoxamine, paroxetine, sertraline). |
| Adverse Reactions |
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Asthenia, nausea, dizziness, somnolence, dry mouth, paresthesia, chest/throat/neck symptoms (pain, pressure, tightness), dysphagia, dyspepsia, abdominal pain; rare: serious cardiovascular events. |
| How Supplied |
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Tabs—6 |
| Additional Resources |
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• Related Prescribing Note |
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