Monograph Details
|
|
Ob/Gyn
> Vaginal infections
|
|
FLAGYL |
| Manufacturer |
|
Pfizer Labs |
| Legal Classification |
|
Rx
|
| Pharmacological Class |
|
Antiprotozoal/antibacterial. |
| Generic Name |
|
Metronidazole 250mg, 500mg; scored tabs. |
| Also |
• FLAGYL 375
• FLAGYL I.V. INJECTION
|
| Indications |
|
Trichomoniasis. |
| Children |
|
Not recommended. |
| Adults |
|
250mg 3 times daily for 1 wk. Or, if patient is not pregnant, 2g in 1–2 divided doses on same day. Before repeating course, reconfirm diagnosis and allow 4–6 wks between courses. Treat consorts also. |
| Contraindications |
|
Pregnancy (1st trimester for trichomoniasis). |
| Precautions |
|
CNS disease. Discontinue if neurological symptoms occur. Severe hepatic disease: reduce dose. History of blood dyscrasias. Monitor leukocytes before and after therapy. Elderly: monitor serum levels. Pregnancy (Cat.B, 2nd and 3rd trimesters). Nursing mothers: not recommended. |
| Interactions |
|
Avoid alcohol during and for 3 days after use. Do not give within 2 weeks of disulfiram (possible psychotic reactions). May potentiate oral anticoagulants, phenytoin, lithium. Antagonized by phenobarbital, phenytoin, other hepatic enzyme inducers. May impair phenytoin clearance. Potentiated by cimetidine, other hepatic enzyme inhibitors. Interferes with serum chemistry tests. |
| Adverse Reactions |
|
GI upset, headache, metallic taste, dysuria, cystitis, incontinence, Candida overgrowth, seizures, peripheral neuropathy, ECT changes; neutropenia, pancreatitis (rare). |
| How Supplied |
Tabs—50, 100
ER—30
Caps 375mg—50 |
| Additional Resources |
|
• Related Prescribing Note |
|
|
|
|
