Monograph Details
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Ob/Gyn
> Vaginal infections
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DIFLUCAN 150mg |
| Manufacturer |
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Pfizer Labs |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Azole antifungal. |
| Generic Name |
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Fluconazole 150mg; tabs. |
| Indications |
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Vaginal candidiasis. |
| Children |
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Not recommended. |
| Adults |
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150mg orally once. |
| Contraindications |
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Concomitant cisapride. |
| Precautions |
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Proarrhythmic conditions. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended. |
| Interactions |
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See Contraindications. Potentiates warfarin, theophylline, oral hypoglycemics, midazolam. May increase serum levels of phenytoin, cyclosporine, zidovudine, sulfonylureas. Thiazides increase fluconazole levels. Monitor levels and/or effects of cyclosporine, phenytoin, sulfonylureas, rifabutin, tacrolimus, theophylline, warfarin. Cimetidine (oral), rifampin may decrease fluconazole levels. Oral contraceptives: see literature. Avoid other hepatotoxic drugs. Caution with other drugs metabolized by CYP450. |
| Adverse Reactions |
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Headache, nausea, abdominal pain, GI upset, dizziness, taste perversion; hepatotoxicity, exfoliative dermatitis (rare). |
| How Supplied |
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Tabs 150mg—1 |
| Additional Resources |
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• Related Prescribing Note |
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