Monograph Details
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Ob/Gyn
> Miscellaneous Ob/Gyn conditions
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LUPRON DEPOT 3.75mg |
| Manufacturer |
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TAP Pharmaceutical Products, Inc. |
| Legal Classification |
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Rx
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| Pharmacological Class |
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GnRH analogue. |
| Generic Name |
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Leuprolide acetate 3.75mg; depot susp for IM inj; preservative-free. |
| Also |
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• LUPRON DEPOT-3 MONTH 11.25mg
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| Indications |
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Presurgical treatment of patients with anemia due to uterine leiomyomata (fibroids), with iron therapy if iron therapy alone is inadequate. |
| Children |
<18 years: not applicable.
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| Adults |
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≥18 years: 3.75mg IM once per month for up to 3 months. |
| Contraindications |
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Undiagnosed abnormal vaginal bleeding. Pregnancy (Cat.X). Nursing mothers. |
| Precautions |
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Exclude pregnancy before starting; use nonhormonal contraception during therapy; discontinue if pregnancy occurs. Risk factors for decreased bone mineral density (eg, chronic alcohol, tobacco, anticonvulsants, corticosteroids). Missing successive doses may cause breakthrough bleeding or ovulation. Elderly. |
| Adverse Reactions |
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Hot flashes, headache, vaginitis, depression, emotional lability, pain, decreased libido, breast changes, amenorrhea, mastodynia, joint disorder, asthenia, GI upset, edema, bone density loss, local reactions, acne, memory disorders, others; rarely: anaphylaxis, asthma, increased serum transaminases or lipids. |
| How Supplied |
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Kit—1 (single-dose syringe w. diluent, supplies) |
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