Monograph Details
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Ob/Gyn
> Menopause and HRT
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CLIMARA PRO |
| Manufacturer |
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Bayer Corp, Pharmaceutical Div. |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Estrogen + progestin. |
| Generic Name |
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Estradiol 0.045mg + levonorgestrel 0.015mg; per day; transdermal system. |
| Indications |
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Moderate to severe vasomotor symptoms of menopause in women with an intact uterus. Postmenopausal osteoporosis prevention. |
| Children |
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Not applicable. |
| Adults |
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Apply 1 patch once weekly to lower abdomen (avoid waistline); rotate application sites. |
| Contraindications |
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Undiagnosed abnormal genital bleeding. Thromboembolic disorders. Thrombophlebitis. Breast or estrogen-dependent carcinoma. Pregnancy (Cat.X). |
| Precautions |
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Familial hyperlipoproteinemia or history of breast cancer. Hepatic insufficiency. Conditions aggravated by fluid retention. Endometriosis. Gallbladder disease. Bone disease associated with hypercalcemia. Do initial complete physical and repeat annually (include Pap smear, mammogram, and BP). Discontinue if visual abnormalities, hypertension or jaundice occurs and during immobilization, or at least 2 weeks before surgery associated with increased risk of thromboembolism. May interfere with lab tests (see literature). Nursing mothers. |
| Adverse Reactions |
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See literature. May increase risk of breast cancer, gallbladder disease, thromboembolic disorders, others. Local irritation, fluid retention, breakthrough bleeding, mastodynia, nausea, abdominal cramps, headache, dizziness, intolerance to contact lenses. |
| How Supplied |
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Patches—4 |
| Additional Resources |
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• Related Prescribing Note |
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