Monograph Details
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Ob/Gyn
> Menopause and HRT
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AYGESTIN |
| Manufacturer |
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Duramed Pharmaceuticals, Inc. |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Progestin. |
| Generic Name |
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Norethindrone acetate 5mg; scored tabs. |
| Indications |
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Secondary amenorrhea, abnormal uterine bleeding due to hormonal imbalance without organic pathology. |
| Children |
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Not applicable. |
| Adults |
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2.5–10mg daily for 5–10 days during 2nd half of theoretical menstrual cycle after estrogens if needed. |
| Contraindications |
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Thromboembolic disorders. Hepatic dysfunction. Undiagnosed vaginal bleeding. Breast or genital carcinoma. Missed abortion. Pregnancy (Cat.X). |
| Precautions |
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Cardiac or renal dysfunction. Depression. Include Pap smear in pretreatment exam. Conditions aggravated by fluid retention. Discontinue if jaundice, visual disturbances, migraine, or thrombotic disorders occur. Nursing mothers. |
| Interactions |
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Rifampin may increase metabolism. |
| Adverse Reactions |
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Menstrual and cervical changes, edema, jaundice, rash, depression, mastodynia, decreased glucose tolerance, weight changes, thromboembolic disease, breakthrough bleeding, melasma, chloasma. |
| How Supplied |
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Tabs—50 |
| Additional Resources |
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• Related Prescribing Note |
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