Monograph Details
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Ob/Gyn
> Infertility
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ENDOMETRIN |
| Manufacturer |
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Ferring Pharmaceuticals, Inc. |
| Legal Classification |
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Rx
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| Generic Name |
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Progesterone (micronized) 100mg; vaginal insert. |
| Indications |
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To support embryo implantation and early pregnancy by supplementation of corpus luteal function as part of an Assisted Reproductive Technology (ART) treatment program for infertile women. |
| Children |
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Not applicable. |
| Adults |
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100mg vaginally 2 or 3 times daily starting at oocyte retrieval for up to 10 weeks total duration. ≥35yrs: efficacy not clearly established; see literature. |
| Contraindications |
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Breast carcinoma. Liver dysfunction or disease. Missed abortion. Ectopic pregnancy. Thrombophlebitis or thromboembolic disorders. |
| Precautions |
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Depression. Discontinue if signs of thrombotic disorders (eg, thrombophlebitis, cerebrovascular disorders, pulmonary embolism, retinal thrombosis) occur. Pregnancy outcome: see literature. Nursing mothers. |
| Interactions |
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Concomitant other vaginal products (eg, antifungals): not recommended. |
| Adverse Reactions |
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GI upset, abdominal pain, post-oocyte retrieval pain, ovarian hyperstimulation syndrome, headache, uterine spasm, vaginal bleeding, fatigue, urinary tract infection. |
| How Supplied |
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Inserts—21 (w. applicators) |
| Additional Resources |
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• Related Prescribing Note |
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