Monograph Details
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Ob/Gyn
> Infertility
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CRINONE |
| Manufacturer |
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EMD Serono, Inc. |
| Legal Classification |
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Rx
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| Generic Name |
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Progesterone (micronized) 8% (90mg/applicatorful); vaginal gel; contains mineral oil. |
| Indications |
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Progesterone supplementation or replacement as part of an Assisted Reproductive Technology (ART) treatment for infertile women with progesterone deficiency. |
| Children |
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Not applicable. |
| Adults |
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Supplementation: 1 applicatorful intravaginally once daily. Replacement: 1 applicatorful intravaginally twice daily. If pregnancy occurs, may continue treatment until placental autonomy is achieved (10–12 weeks). |
| Contraindications |
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Undiagnosed vaginal bleeding. Breast or genital carcinoma. Liver dysfunction or disease. Missed abortion. Thrombophlebitis or thromboembolic disorders. |
| Precautions |
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Conditions aggravated by fluid retention. Depression. Include Pap smear with pretreatment exam. Discontinue if signs of thrombotic disorders (eg, thrombophlebitis, cerebrovascular disorders, pulmonary embolism, retinal thrombosis) occur. Pregnancy: see literature. Nursing mothers. |
| Interactions |
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Allow at least 6 hours between administration of this and other vaginally-administered products. |
| Adverse Reactions |
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Mastodynia, constipation, somnolence, GI upset, headache, abdominal/perineal pain, nervousness, cramps, nocturia, depression, decreased libido, arthralgia, bloating, pain, vaginal candidiasis/discharge, dizziness, dyspareunia, pruritus genital, allergy, fatigue, urinary tract infection, others. |
| How Supplied |
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Prefilled applicators—18 |
| Additional Resources |
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• Related Prescribing Note |
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