Monograph Details
|
|
Ob/Gyn
> Endometriosis
|
|
AYGESTIN |
| Manufacturer |
|
Duramed Pharmaceuticals, Inc. |
| Legal Classification |
|
Rx
|
| Pharmacological Class |
|
Progestin. |
| Generic Name |
|
Norethindrone acetate 5mg; scored tabs. |
| Indications |
|
Endometriosis. |
| Children |
|
Not applicable. |
| Adults |
|
Initially 5mg daily for 2 weeks, then increase by 2.5mg/day every 2 weeks up to 15mg/day maintenance dose. Continue for 6–9 months unless breakthrough bleeding is intolerable. |
| Contraindications |
|
Thromboembolic disorders. Hepatic dysfunction. Undiagnosed vaginal bleeding. Breast or genital carcinoma. Missed abortion. Pregnancy (Cat.X). |
| Precautions |
|
Cardiac or renal dysfunction. Depression. Include Pap smear in pretreatment exam. Conditions aggravated by fluid retention. Discontinue if jaundice, visual disturbances, migraine, or thrombotic disorders occur. Nursing mothers. |
| Interactions |
|
Rifampin may increase metabolism. |
| Adverse Reactions |
|
Menstrual and cervical changes, edema, jaundice, rash, depression, mastodynia, decreased glucose tolerance, weight changes, thromboembolic disease, breakthrough bleeding, melasma, chloasma. |
| How Supplied |
|
Tabs—50 |
|
|
|
|
