Monograph Details
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Ob/Gyn
> Dysmenorrhea
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CELEBREX |
| Manufacturer |
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Pfizer Labs |
| Legal Classification |
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Rx
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| Pharmacological Class |
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NSAID (COX-2 inhibitor). |
| Generic Name |
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Celecoxib 50mg, 100mg, 200mg, 400mg; caps. |
| Indications |
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Dysmenorrhea. |
| Children |
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Not recommended. |
| Adults |
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≥18yrs: 400mg once then 200mg more on 1st day if needed, then 200mg twice daily. <50kg: start at lowest recommended dose. |
| Contraindications |
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Sulfonamide or aspirin allergy. 3rd trimester pregnancy. Coronary artery bypass graft surgery. |
| Precautions |
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Advanced renal disease or severe hepatic impairment: not recommended. Renal or liver dysfunction; reduce dose by 50% in moderate hepatic insufficiency (Child-Pugh class B). Discontinue if liver disease or systemic effects (eg, eosinophilia, rash) develops. History or risk of GI bleed/ulcer (monitor). Fluid retention. Heart failure. Hypertension. Asthma. Alcoholism. Dehydrated. Elderly. Debilitated. Labor & delivery. Pregnancy (Cat.C). Nursing mothers: not recommended. |
| Interactions |
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Caution with drugs that inhibit CYP2C9 (eg, fluconazole) or are metabolized by CYP2D6. May antagonize, or increase risk of renal failure with ACEIs, diuretics. Increased risk of GI bleed with aspirin (except low-dose), corticosteroids, smoking, anticoagulants. May potentiate lithium. Monitor warfarin. |
| Adverse Reactions |
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GI upset/pain, edema, pharyngitis, increase AST/ALT, GI ulcer/bleed; rare: intracranial bleed, liver failure. See literature re: risk of cardiovascular events. |
| How Supplied |
Caps 100mg, 200mg—100, 500
50mg, 400mg—60 |
| Additional Resources |
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• Related Prescribing Note |
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