Monograph Details
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Ob/Gyn
> Contraception
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LYBREL |
| Manufacturer |
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Wyeth Pharmaceuticals |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Progestin + estrogen. |
| Generic Name |
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Levonorgestrel 0.09mg, ethinyl estradiol 20micrograms; tabs. |
| Indications |
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Oral contraception. |
| Children |
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Premenarchal: not recommended. |
| Adults |
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Take at same time each day. 1 tab daily (no tablet-free days). Start on Day 1 of cycle. Switching from other contraceptives or post-partum: see literature; may need back-up method for 1st week. |
| Contraindications |
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Thrombophlebitis or thromboembolic disorders. Cerebrovascular or coronary artery disease. Valvular heart disease. Breast or other estrogen-dependent neoplasias. Undiagnosed abnormal genital bleeding. Cholestatic jaundice of pregnancy or jaundice with prior oral contraceptive use. Uncontrolled hypertension. Prolonged immobilization. Diabetes with vascular involvement. Headaches with focal neurological symptoms. Liver tumors or disease. Pregnancy (Cat.X). |
| Precautions |
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Smokers >35 years old: not recommended. Hypertriglyceridemia. Discontinue if jaundice, visual disturbances, migraine, or other severe headaches occur. Do regular complete physical exams. Nursing mothers: not recommended. |
| Interactions |
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Antagonized by hepatic enzyme inducing drugs (eg, rifampin, griseofulvin, St. John's Wort, carbamazepine, phenytoin, protease inhibitors), others. Ethinyl estradiol levels may be increased by atorvastatin, CYP3A4 inhibitors, others. May affect measurement of sex hormone binding globulin levels. |
| Adverse Reactions |
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Hypertension, nausea, vomiting, breakthrough bleeding, amenorrhea, transient delay in ovulation after discontinuation, edema, chloasma, mastodynia, headache, intolerance to contact lenses, increased risk of gallbladder disease, thromboembolic events. |
| How Supplied |
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ClickCase (28 tabs)—1 |
| Additional Resources |
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• Related Prescribing Note |
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