Monograph Details
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Nutrition
> Anorexia/cachexia
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MARINOL |
| Manufacturer |
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Unimed Pharmaceuticals, Inc. |
| Legal Classification |
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CIII |
| Pharmacological Class |
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Cannabinoid. |
| Generic Name |
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Dronabinol 2.5mg, 5mg, 10mg; caps; contains sesame oil. |
| Indications |
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Anorexia with weight loss in AIDS patients. |
| Children |
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Not recommended. |
| Adults |
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Individualize. Initially 2.5mg twice daily before lunch and supper. If intolerable, may reduce to 2.5mg once in the evening. May increase gradually to max 20mg/day in divided doses. |
| Precautions |
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Seizure or cardiac disorders. History of psychiatric disorders (eg, mania, depression, schizophrenia) or substance abuse. Write Rx for smallest practical amount. Keep patient under responsible adult supervision (esp. when dose is adjusted). Children. Elderly (monitor: esp. with dementia). Pregnancy (Cat.C). Nursing mothers: not recommended. |
| Interactions |
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Potentiates CNS depression with benzodiazepines, barbiturates, alcohol, other CNS depressants and other psychoactive substances (avoid). May affect, or be affected by other drugs that are highly protein bound (eg, sympathomimetics, anticholinergics, tricyclic antidepressants). Antagonizes theophylline. |
| Adverse Reactions |
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Psychomimetic reactions, euphoria, depression, behavior disorders, drowsiness, dizziness, fatigue, somnolence, altered mental status, seizures (discontinue if occurs), ataxia, anxiety, paresthesia, tachycardia, hypotension, vasodilation, tolerance and withdrawal syndrome. |
| How Supplied |
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Caps—60 |
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