Monograph Details
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Neoplasms
> Topoisomerase inhibitors
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HYCAMTIN |
| Manufacturer |
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GlaxoSmithKline Pharmaceuticals |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Topoisomerase inhibitor. |
| Generic Name |
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Topotecan (as HCl) 4mg/vial; pwd for IV infusion after reconstitution and dilution; contains mannitol; preservative-free. |
| Also |
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• HYCAMTIN CAPSULES
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| Indications |
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Metastatic carcinoma of the ovary after failure of initial or subsequent chemotherapy. Small cell lung cancer sensitive disease after failure of 1st line chemotherapy. Stage IV-B, recurrent or persistent carcinoma of the cervix in combination with cisplatin. |
| Children |
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Not recommended. |
| Adults |
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Give by IV infusion over 30 minutes. Ovarian cancer, small cell lung cancer: 1.5mg/m2 daily for 5 consecutive days starting on Day 1 of a 21-day cycle. Cervical cancer: 0.75mg/m2 on Days 1, 2, and 3; followed by cisplatin. Dose adjustments: see literature. |
| Contraindications |
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Severe bone marrow depression. Pregnancy (Cat.D). Nursing mothers. |
| Precautions |
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Monitor peripheral blood cell counts; hold dose until neutrophils >1,000cells/mm3, platelets >100,000cells/mm3, and hemoglobin ≥9g/dL. Moderate to severe renal impairment. Caps: severe diarrhea; may need to reduce dose. IV: avoid extravasation. Elderly. |
| Interactions |
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Myelosuppression potentiated with platinum agents. IV: Neutropenia potentiated by G-CSF. Caps: Avoid concomitant P-glycoprotein inhibitors (eg, cyclosporine A, elacridar, ketoconazole, ritonavir, saquinavir). |
| Adverse Reactions |
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See literature. Neutropenia, leukopenia, thrombocytopenia, anemia, GI upset, anorexia, abdominal pain, stomatitis, headache, dyspnea, cough, pyrexia, alopecia, fatigue; infection, sepsis, neutropenic colitis (may be fatal). |
| How Supplied |
Single-use vials—1, 5
Caps—10 |
| Additional Resources |
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• Related Prescribing Note |
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