Monograph Details
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Neoplasms
> Monoclonal antibodies
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AVASTIN |
| Manufacturer |
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Genentech, Inc. |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Angiogenesis inhibitor. |
| Generic Name |
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Bevacizumab 100mg, 400mg; per vial; soln for IV infusion after dilution; preservative-free. |
| Indications |
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Metastatic colorectal carcinoma, in combination with 5-FU-based chemotherapy. First-line treatment of unresectable, locally advanced, recurrent or metastatic non-squamous, non-small cell lung cancer (NSCLC), in combination with carboplatin and paclitaxel. Metastatic HER2-negative breast cancer in patients who have not received chemotherapy, in combination with paclitaxel. |
| Children |
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Not recommended. |
| Adults |
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Give by IV infusion after chemotherapy. Infuse 1st dose over 90 minutes; if tolerated, infuse 2nd dose over 60 minutes, and subsequent doses over 30 minutes. Metastatic colorectal carcinoma: 5mg/kg (when used with bolus-IFL) or 10mg/kg (when used with FOLFOX-4) once every 14 days until disease progression detected. NSCLC: 15mg/kg once every 3 weeks. Breast cancer: 10mg/kg once every 14 days. |
| Contraindications |
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Recent hemoptysis. |
| Precautions |
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Not used for breast cancer that has progressed after anthracycline and taxane chemotherapy. Do not start therapy before or for at least 28 days after surgery; allow surgical incisions to completely heal (see literature). Discontinue if GI perforation, significant wound dehiscence, serious hemorrhage, severe arterial thromboembolic events, hypertensive crisis or nephrotic syndrome occurs; suspend therapy if severe hypertension or moderate to severe proteinuria occurs. Cardiovascular disease. Renal or hepatic impairment. Check BP every 2–3 weeks. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended. |
| Adverse Reactions |
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Gastrointestinal perforation, wound dehiscence/impaired healing, hemorrhage, arterial thromboembolic events (may be fatal), hypertensive crisis, nephrotic syndrome, neutropenia, CHF, asthenia, pain, GI upset, abdominal pain, hypertension, leukopenia, headache, fatigue, anorexia, stomatitis, dyspnea, upper respiratory infection, constipation, epistaxis, proteinuria, thrombosis, syncope. |
| How Supplied |
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Single-use vial—1 |
| Additional Resources |
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• Related Prescribing Note |
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