Monograph Details
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Neoplasms
> Hormones and antagonists
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LUPRON DEPOT-4 MONTH 30mg |
| Manufacturer |
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TAP Pharmaceutical Products, Inc. |
| Legal Classification |
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Rx
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| Pharmacological Class |
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GnRH analogue. |
| Generic Name |
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Leuprolide acetate 30mg; depot susp for IM inj; preservative-free. |
| Also |
• LUPRON DEPOT-3 MONTH 22.5mg
• LUPRON DEPOT 7.5mg
• LUPRON INJECTION
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| Indications |
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Palliative treatment of advanced prostatic carcinoma. |
| Children |
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Not applicable. |
| Adults |
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30mg as single IM inj every 4 months (16 weeks). Do not split doses. |
| Precautions |
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May use SC form for first 2 weeks of treatment for patients at risk of worsening symptoms of metastatic vertebral lesions and/or urinary obstruction to facilitate treatment withdrawal. Metastatic vertebral lesions. Urinary obstruction. Monitor serum testosterone, PSA, acid phosphatase. Instruct patient on correct self administration. |
| Adverse Reactions |
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Hot flashes, initial worsening of signs/symptoms (eg, bone pain, urinary tract obstruction, hematuria), edema, GI upset, pain, cardiovascular events, CNS and antiandrogenic effects, asthenia, spinal cord compression; anaphylactoid, photosensitivity, local reactions. |
| How Supplied |
Depot single-dose syringe—1 (w. diluent)
Inj multidose vial (2.8mL)—1 |
| Additional Resources |
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• Related Prescribing Note |
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