Monograph Details
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Neoplasms
> Hormones and antagonists
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CASODEX |
| Manufacturer |
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AstraZeneca Pharmaceuticals |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Antiandrogen. |
| Generic Name |
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Bicalutamide 50mg; tabs. |
| Indications |
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In combination with luteinizing hormone-releasing hormone (LHRH) analogue in stage D2 metastatic prostate carcinoma. |
| Children |
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Not applicable. |
| Adults |
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Take at the same time each day. 50mg daily. Start treatment at same time as starting LHRH analogue. |
| Contraindications |
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Women of childbearing potential. Pregnancy (Cat.X). |
| Precautions |
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Moderate to severe hepatic impairment. Monitor prostate specific antigen and hepatic function (discontinue if ALT >2xULN or if jaundice occurs). Nursing mothers. |
| Interactions |
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Monitor oral anticoagulants. |
| Adverse Reactions |
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Hot flashes, gynecomastia, breast pain, diarrhea, pain, asthenia, infection, dyspnea, impotence, loss of libido, others (see literature); rare: hepatitis. |
| How Supplied |
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Tabs—30, 100 |
| Additional Resources |
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• Related Prescribing Note |
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