Monograph Details
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Neoplasms
> Hormones and antagonists
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ARIMIDEX |
| Manufacturer |
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AstraZeneca Pharmaceuticals |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Aromatase inhibitor. |
| Generic Name |
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Anastrozole 1mg; tabs. |
| Indications |
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In postmenopausal women: adjuvant treatment of hormone receptor-positive early breast cancer; first-line treatment of hormone receptor-positive or unknown locally advanced or metastatic breast cancer; advanced breast cancer with disease progression after tamoxifen therapy. |
| Children |
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Not applicable. |
| Adults |
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1mg once daily. Advanced disease: continue until tumor progression. |
| Precautions |
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Severe hepatic impairment. Monitor bone mineral density. Pregnancy (Cat.D); avoid use. Nursing mothers. |
| Interactions |
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Antagonized by tamoxifen, estrogens; do not give concomitantly. |
| Adverse Reactions |
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Asthenia, GI upset, headache, hot flashes, pain, hypertension, dyspnea, dizziness, rash, osteoporosis, fractures, peripheral edema, insomnia, depression, paresthesia, vaginal bleeding, cough, arthralgia, hypercholesterolemia. |
| How Supplied |
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Tabs—30 |
| Additional Resources |
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• Related Prescribing Note |
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