Monograph Details
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Neoplasms
> Cytoprotective agents
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MESNEX TABLETS |
| Manufacturer |
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Bristol-Myers Squibb |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Cytoprotective agent. |
| Generic Name |
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Mesna 400mg; tabs. |
| Also |
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• MESNEX INJECTION
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| Indications |
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Prophylactic agent in reducing the incidence of ifosfamide-induced hemorrhagic cystitis. |
| Children |
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Not recommended. |
| Adults |
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See literature. IV Schedule: Give as IV bolus injection in a dosage equal to 20% of the ifosfamide dose at the time of ifosfamide administration and 4 and 8 hours after each dose of ifosfamide; total daily dose is 60% the ifosfamide dose. IV and oral dosing: Give as IV bolus injection in a dosage equal to 20% of the ifosfamide dose at the time of ifosfamide administration, followed by the tablets given orally in a dosage equal to 40% of the ifosfamide dose 2 and 6 hours after each dose of ifosfamide; total daily dose is 100% of the ifosfamide dose. Repeat schedule on each day ifosfamide is given. If vomiting occurs within 2hrs of oral mesna, repeat dose or give IV mesna. |
| Contraindications |
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Hypersensitivity to thiol compounds. |
| Precautions |
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Monitor morning specimen of urine for the presence of hematuria each day prior to ifosfamide therapy; consider dose reduction or discontinue if hematuria occurs. Elderly. Pregnancy (Cat.B). Nursing mothers: not recommended. |
| Adverse Reactions |
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GI upset, fever, anorexia, flatulence, constipation, rhinitis, rigors, back pain, rash, conjunctivitis, arthralgia, headache, inj site reactions, flushing, dizziness, pharyngitis, hyperaesthesia, flu-like symptoms, coughing; hypersensitivity reactions. |
| Extra Text |
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Note: Patients taking mesna should drink at least a quart of liquid a day. |
| How Supplied |
Tabs—10
Multidose vials—1, 10 |
| Additional Resources |
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• Related Prescribing Note |
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