Monograph Details
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Musculoskeletal Disorders
> Muscle spasms
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VALIUM INJECTION |
| Manufacturer |
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Roche Laboratories |
| Legal Classification |
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CIV |
| Pharmacological Class |
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Benzodiazepine. |
| Generic Name |
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Diazepam 5mg/mL; contains propylene glycol 40%, ethyl and benzyl alcohol. |
| Also |
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• VALIUM
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| Indications |
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Skeletal muscle spasm. |
| Children |
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Max 0.25mg/kg over 3 minutes; if no response after 3rd dose consider adjunctive therapy. Tetanus: age <30 days: not recommended. 30 days to 5 years: 1–2mg IM or slow IV. >5yrs: 5–10mg IM or slow IV. Both: may repeat after 3–4 hours. Do not use small vein. |
| Adults |
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Initially 5–10mg slow IV (5mg/min) or IM. May repeat after 3–4 hours. Tetanus: may need larger dose. Do not use small vein. |
| Contraindications |
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Acute narrow-angle glaucoma. |
| Precautions |
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Not for use in untreated open-angle glaucoma. Inj not for use in shock, coma, acute alcohol intoxication, or obstetrical conditions. Discontinue if paradoxical reaction occurs. Drug or alcohol abuse. Depression. Suicidal tendencies. Renal or liver dysfunction. Avoid abrupt cessation. May increase tonic-clonic seizures. Reevaluate periodically. Monitor blood counts, liver function. Elderly. Debilitated. Psychosis, pregnancy, nursing mothers: not recommended. |
| Interactions |
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Potentiates CNS depression with alcohol, other CNS depressants (consider reducing opioid doses by at least ⅓). Increased serum levels with cimetidine. Potentiated by sertraline. Inj: hypotension, muscle weakness with narcotics, barbiturates, alcohol. |
| Adverse Reactions |
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CNS depression, ataxia, memory impairment, paradoxical excitement, salivation changes, neutropenia, jaundice. Inj: apnea, cardiac arrest, venous thrombosis, phlebitis, status epilepticus (when treating petit mal). |
| How Supplied |
Tabs 2mg—100
Tabs 5mg, 10mg—100, 500
Vials (10mL)—1 |
| Additional Resources |
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• Related Prescribing Note |
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