Monograph Details
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Musculoskeletal Disorders
> Muscle spasms
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VALIUM |
| Manufacturer |
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Roche Laboratories |
| Legal Classification |
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CIV |
| Pharmacological Class |
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Benzodiazepine. |
| Generic Name |
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Diazepam 2mg, 5mg, 10mg; scored tabs. |
| Also |
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• VALIUM INJECTION
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| Indications |
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Skeletal muscle spasm. |
| Children |
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<6months: not recommended. ≥6months: initially 1–2.5mg 3–4 times daily; increase gradually. |
| Adults |
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2–10mg 3–4 times daily. Elderly, debilitated: initially 2–2.5mg 1–2 times daily; increase gradually. |
| Contraindications |
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Acute narrow-angle glaucoma. |
| Precautions |
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Not for use in untreated open-angle glaucoma. Inj not for use in shock, coma, acute alcohol intoxication, or obstetrical conditions. Discontinue if paradoxical reaction occurs. Drug or alcohol abuse. Depression. Suicidal tendencies. Renal or liver dysfunction. Avoid abrupt cessation. May increase tonic-clonic seizures. Reevaluate periodically. Monitor blood counts, liver function. Elderly. Debilitated. Psychosis, pregnancy, nursing mothers: not recommended. |
| Interactions |
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Potentiates CNS depression with alcohol, other CNS depressants (consider reducing opioid doses by at least ⅓). Increased serum levels with cimetidine. Potentiated by sertraline. Inj: hypotension, muscle weakness with narcotics, barbiturates, alcohol. |
| Adverse Reactions |
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CNS depression, ataxia, memory impairment, paradoxical excitement, salivation changes, neutropenia, jaundice. Inj: apnea, cardiac arrest, venous thrombosis, phlebitis, status epilepticus (when treating petit mal). |
| How Supplied |
Tabs 2mg—100
Tabs 5mg, 10mg—100, 500
Vials (10mL)—1 |
| Additional Resources |
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• Related Prescribing Note |
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