Monograph Details
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Musculoskeletal Disorders
> Muscle spasms
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AMRIX |
| Manufacturer |
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Cephalon, Inc. |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Muscle relaxant (central). |
| Generic Name |
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Cyclobenzaprine HCl 15mg, 30mg; ext-rel caps. |
| Indications |
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Adjunct to rest and physical therapy for relief of muscle spasm associated with acute, painful musculoskeletal conditions. |
| Children |
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Not recommended. |
| Adults |
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Take at same time each day. 15mg once daily; may increase to 30mg/day given once daily. Max 2–3 weeks. Elderly or hepatic impairment: not recommended. |
| Contraindications |
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Acute post-MI. Arrhythmias, heart block, other conduction disturbances. CHF. Hyperthyroidism. During or within 14 days of MAOIs. |
| Precautions |
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Hepatic impairment or elderly: not recommended. Urinary retention. Angle-closure glaucoma. Increased intraocular pressure. Pregnancy (Cat.B). Nursing mothers. |
| Interactions |
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See Contraindications. Hypertensive crisis with MAOIs. Potentiates anticholinergics, alcohol, other CNS depressants. May antagonize guanethidine, clonidine. May enhance seizure risk with concomitant tramadol. |
| Adverse Reactions |
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Drowsiness, dry mouth, dizziness, fatigue, headache, GI upset, dysgeusia, tremor, nervousness, asthenia, blurred vision, confusion. |
| How Supplied |
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Caps—60 |
| Additional Resources |
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• Related Prescribing Note |
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