Monograph Details
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Musculoskeletal Disorders
> Gout
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ZYLOPRIM |
| Manufacturer |
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Prometheus Labs, Inc. |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Xanthine oxidase inhibitor. |
| Generic Name |
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Allopurinol 100mg, 300mg; scored tabs. |
| Indications |
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Gout. |
| Children |
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Not recommended. |
| Adults |
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Take with food. Initially 100mg daily. Maintain prophylactic therapy initially. Increase by 100mg daily increments at weekly intervals; max 800mg/day and 300mg/dose. Usual range: mild: 200–300mg daily; severe: 400–600mg daily. |
| Precautions |
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Discontinue if rash occurs. Renal or hepatic dysfunction. Monitor blood, renal, and hepatic tests for first few months of therapy. Maintain neutral or alkaline urine and increase urine output to ≥2 liters daily. Pregnancy (Cat.C). Nursing mothers. |
| Interactions |
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Increase in azathioprine and mercaptopurine toxicity. May potentiate oral anticoagulants, chlorpropamide, cyclosporine. Uricosurics reduce drug effect. Increased rash with ampicillin, amoxicillin. Monitor renal function with thiazides. |
| Adverse Reactions |
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Rash, GI disorders, acute gout, ecchymosis, fever, headache, hepatic necrosis, drowsiness, neuritis, arthralgia, necrotizing angiitis, blood dyscrasias, bone marrow depression, toxic skin reactions (eg, Stevens-Johnson syndrome), renal failure. |
| How Supplied |
100mg—100
300mg—100, 500 |
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