Monograph Details
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Musculoskeletal Disorders
> Arthritis/rheumatic disorders
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VOLTAREN-XR |
| Manufacturer |
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Novartis Pharmaceuticals Corp |
| Legal Classification |
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Rx
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| Pharmacological Class |
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NSAID (benzeneacetic acid deriv.). |
| Generic Name |
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Diclofenac sodium 100mg; ext-rel tabs. |
| Also |
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• VOLTAREN
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| Indications |
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Chronic therapy of osteoarthritis or rheumatoid arthritis. |
| Children |
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Not recommended. |
| Adults |
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Osteoarthritis: 100mg once daily. Rheumatoid arthritis: 100mg once daily; rarely 100mg twice daily may be used. |
| Contraindications |
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Aspirin allergy. Late pregnancy. Coronary artery bypass graft surgery. |
| Precautions |
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Advanced renal disease: not recommended. Peptic ulcers and GI bleeding. Check SGPT/SGOT within 4 weeks and then periodically. Edema. Cardiac failure. Hypertension. Bleeding disorders. Renal impairment. Hepatic porphyria. Monitor blood, hepatic, renal, and ocular function in chronic use. Elderly. Debilitated. Pregnancy (Cat.C). Nursing mothers: not recommended. |
| Interactions |
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Digoxin, methotrexate, cyclosporine, lithium toxicity. Hyper- and hypoglycemia with insulin and sulfonylureas. Reduced effect of diuretics. Increased serum potassium level with K+ sparing diuretics. Avoid aspirin. Monitor oral anticoagulants. |
| Adverse Reactions |
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Peptic ulcers, GI bleeding, elevated SGPT or SGOT levels, anaphylactoid reactions, abdominal discomfort, constipation, diarrhea, indigestion, nausea, abdominal distention, headache, dizziness, fluid retention, rash (discontinue if occurs), pruritus, tinnitus. See literature re: risk of cardiovascular events. |
| How Supplied |
XR—100
Tabs 25mg—60, 100
50mg, 75mg—60, 100, 1000 |
| Additional Resources |
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• Related Prescribing Note |
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