Monograph Details
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Musculoskeletal Disorders
> Arthritis/rheumatic disorders
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Salsalate |
| Manufacturer |
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Various generic manufacturers |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Salicylate. |
| Generic Name |
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Salsalate 500mg, 750mg; scored tabs. |
| Also |
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• Salsalate capsules
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| Indications |
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Rheumatoid arthritis. Osteoarthritis. |
| Children |
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Not recommended. |
| Adults |
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3g daily in divided doses. |
| Contraindications |
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Varicella or influenza in teenagers. 3rd trimester pregnancy. Aspirin allergy. Coronary artery bypass graft surgery. |
| Precautions |
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Advanced renal disease: not recommended. Impaired renal or hepatic function. Hypertension. Heart failure. Edema. Bleeding disorders. Monitor blood, liver, renal function with chronic use. Peptic ulcer. Gastritis. Diabetes. Elderly. Debilitated. Pregnancy (Cat.C). Nursing mothers: not recommended. |
| Interactions |
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PABA may increase serum levels. May potentiate anticoagulants, hypoglycemics, methotrexate. Urinary alkalinizers, antacids, corticosteroids may increase excretion. May antagonize uricosurics and spironolactone. |
| Adverse Reactions |
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Salicylism, tinnitus, nausea, dyspepsia, GI bleed, hearing loss, rash (discontinue if occurs). See literature re: risk of cardiovascular events. |
| How Supplied |
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Contact supplier. |
| Additional Resources |
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• Related Prescribing Note |
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