Monograph Details
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Musculoskeletal Disorders
> Arthritis/rheumatic disorders
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ORUVAIL |
| Manufacturer |
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Wyeth Pharmaceuticals |
| Legal Classification |
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Rx
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| Pharmacological Class |
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NSAID (propionic acid deriv.). |
| Generic Name |
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Ketoprofen 100mg, 150mg, 200mg; ext rel; pH-dependent coated pellets in caps. |
| Indications |
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Osteoarthritis. Rheumatoid arthritis. |
| Children |
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Not recommended. |
| Adults |
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200mg daily. Elderly (>75 yrs), debilitated, or small patients: start with lower dose and titrate upwards. |
| Contraindications |
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Aspirin allergy. Late pregnancy. Coronary artery bypass graft surgery. |
| Precautions |
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Advanced renal disease: not recommended. Acute pain. Renal or hepatic dysfunction. Edema. Hypertension. Cardiac failure. History of upper GI disease. Bleeding disorders. Hypoalbuminemia. Monitor blood, hepatic, renal, and ocular function in chronic use. Elderly. Debilitated. Pregnancy (Cat.C). Nursing mothers: not recommended. |
| Interactions |
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Avoid salicylates, probenecid. Renal toxicity potentiated with diuretics. Monitor oral anticoagulants. May increase toxicity of methotrexate. May increase serum lithium levels. |
| Adverse Reactions |
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GI bleeding, peptic ulcer, peripheral edema, dyspepsia, headache, dizziness, drowsiness, nausea, abdominal pain, diarrhea, constipation, flatulence, rash (discontinue if occurs), tinnitus, visual disturbances, GI or CNS disturbances, nephrotoxicity, jaundice. See literature re: risk of cardiovascular events. |
| How Supplied |
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Caps—100 |
| Additional Resources |
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• Related Prescribing Note |
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