Monograph Details
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Musculoskeletal Disorders
> Arthritis/rheumatic disorders
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MOBIC |
| Manufacturer |
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Boehringer Ingelheim Pharmaceuticals |
| Legal Classification |
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Rx
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| Pharmacological Class |
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NSAID (oxicam deriv.). |
| Generic Name |
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Meloxicam 7.5mg, 15mg; tabs. |
| Also |
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• MOBIC ORAL SUSPENSION
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| Indications |
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Osteoarthritis. Rheumatoid arthritis. Juvenile rheumatoid arthritis. |
| Children |
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<2yrs: not recommended. JRA: ≥2yrs: 0.125mg/kg (max 7.5mg) once daily. |
| Adults |
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≥18yrs: 7.5mg once daily; max 15mg once daily. |
| Contraindications |
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Aspirin allergy. 3rd trimester pregnancy. Coronary artery bypass graft surgery. |
| Precautions |
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Severe renal disease (CrCl ≤15mL/min): not recommended. Discontinue if liver dysfunction develops. Monitor for GI ulcer/bleed (risk is increased if history of GI bleed or ulcer, extended or high-dose NSAID therapy, smokers, alcoholics, or if patient is otherwise at high risk). Monitor hemoglobin or hematocrit if signs of anemia occur. Bleeding disorders. Renal or hepatic dysfunction. Dehydration. Fluid retention. Heart failure. Hypertension. Asthma. Elderly. Debilitated. Labor & delivery. Pregnancy (Cat.C). Nursing mothers: not recommended. |
| Interactions |
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Increased risk of GI bleed with aspirin, oral corticosteroids, anticoagulants. May antagonize or increase risk of renal failure with ACE inhibitors, diuretics. Monitor warfarin (may increase INR). May potentiate lithium. |
| Adverse Reactions |
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GI upset, anemia, headache, rash (discontinue if occurs), dizziness, edema, pruritus, GI ulcer/bleed, upper respiratory tract infections, elevated liver enzymes. Children: abdominal pain, pyrexia. See literature re: risk of cardiovascular events. |
| How Supplied |
Tabs—100
Susp—100mL |
| Additional Resources |
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• Related Prescribing Note |
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