Monograph Details
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Musculoskeletal Disorders
> Arthritis/rheumatic disorders
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LODINE |
| Manufacturer |
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Wyeth Pharmaceuticals |
| Legal Classification |
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Rx
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| Pharmacological Class |
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NSAID (pyranocarboxylic acid deriv.). |
| Generic Name |
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Etodolac 200mg, 300mg; caps. |
| Also |
• LODINE TABLETS
• LODINE XL
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| Indications |
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Osteoarthritis. Rheumatoid arthritis. |
| Children |
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Not recommended. |
| Adults |
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Initially 600mg–1g/day in 2–3 divided doses; usual max 1g/day in divided doses; may increase to 1.2g/day when needed. |
| Contraindications |
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Aspirin allergy. Late pregnancy. Coronary artery bypass graft surgery. |
| Precautions |
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Discontinue if signs/symptoms of liver disease develop. History of upper GI disease. Asthma. Renal or hepatic impairment. Advanced kidney disease: not recommended. Heart failure. Hypertension. Edema. Bleeding disorders. Monitor blood, hepatic, renal, and ocular function in chronic use. Dehydrated. Elderly. Debilitated. Labor & delivery. Pregnancy (Cat.C). Nursing mothers: not recommended. |
| Interactions |
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Antacids reduce serum levels. Avoid salicylates, phenylbutazone. Monitor anticoagulants, cyclosporine, lithium, digoxin, methotrexate. Renal toxicity may be potentiated with diuretics. May antagonize ACE inhibitors. |
| Adverse Reactions |
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Dyspepsia, GI upset, edema, asthenia/malaise, dizziness, dysuria, urinary frequency, depression, nervousness, renal or hepatic toxicity, rash (discontinue if occurs), pruritus, chills/fever, GI bleed, peptic ulcer. See literature re: risk of cardiovascular events. |
| How Supplied |
Caps, tabs—100
XL—100 |
| Additional Resources |
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• Related Prescribing Note |
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