Monograph Details
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Musculoskeletal Disorders
> Arthritis/rheumatic disorders
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ECOTRIN |
| Manufacturer |
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GlaxoSmithKline Pharmaceuticals |
| Legal Classification |
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OTC |
| Pharmacological Class |
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Salicylate. |
| Generic Name |
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Aspirin 81mg, 325mg, 500mg; e-c tabs. |
| Indications |
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Arthritic and rheumatic conditions. |
| Children |
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JRA: initially 90–130 mg/kg per day in divided doses; target plasma salicylate level 150–300 micrograms/mL. |
| Adults |
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Rheumatoid arthritis, arthritis and pleurisy of SLE: initially 3 g daily in divided doses; target plasma salicylate level 150–300 micrograms/mL. Osteoarthritis: up to 3 g/day in divided doses. Spondyloarthropathies: up to 4 g/day in divided doses. |
| Contraindications |
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NSAID allergy. Viral infection in children and teenagers. 3rd trimester pregnancy. |
| Precautions |
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History of asthma or peptic ulcer. Severe hepatic or renal dysfunction. Bleeding disorders. Diabetes. Gout. Pregnancy, nursing mothers: not recommended. |
| Interactions |
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Potentiates anticoagulants, hypoglycemics, methotrexate, acetazolamide, valproic acid, highly protein-bound drugs. Urinary alkalinizers, antacids, corticosteroids may increase excretion. May antagonize ACE inhibitors, β-blockers, diuretics, uricosurics. Increased bleeding risk with NSAIDs or chronic, heavy alcohol use. NSAIDs increase risk of renal dysfunction. |
| Adverse Reactions |
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GI upset/bleed, prolonged bleeding time, anaphylaxis, salicylism. |
| How Supplied |
Tabs 81mg—36, 120
325mg—100, 250
500mg—60, 150 |
| Additional Resources |
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• Related Prescribing Note |
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