Monograph Details
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Musculoskeletal Disorders
> Arthritis/rheumatic disorders
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Diflunisal |
| Manufacturer |
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Various generic manufacturers |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Salicylate. |
| Generic Name |
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Diflunisal 250mg, 500mg; tabs. |
| Indications |
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Osteoarthritis. Rheumatoid arthritis. |
| Children |
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Not recommended. |
| Adults |
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250–500mg twice daily; max 1.5g/day. |
| Contraindications |
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Aspirin allergy. Varicella or influenza in teenagers. 3rd trimester pregnancy. Coronary artery bypass graft surgery. |
| Precautions |
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Advanced renal disease: not recommended. Active peptic ulcer or GI bleeding. History of GI disease. Cardiac failure. Hypertension. Impaired renal or hepatic function. Volume depletion. Bleeding disorders. Sepsis. Diabetes. Monitor blood, hepatic, renal, and ocular function in chronic use. Elderly. Debilitated. Pregnancy (Cat.C in 1st and 2nd trimesters). Nursing mothers: not recommended. |
| Interactions |
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Avoid methotrexate, indomethacin. Oral anticoagulants potentiated. Increased acetaminophen and hydrochlorothiazide serum levels. Reduced absorption with antacids. |
| Adverse Reactions |
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Peptic ulcer, GI bleeding, nausea, dyspepsia, GI pain, diarrhea, rash (discontinue if occurs), headache, dizziness, edema, nephritis. See literature re: risk of cardiovascular disease. |
| How Supplied |
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Contact supplier. |
| Additional Resources |
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• Related Prescribing Note |
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