Monograph Details
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Musculoskeletal Disorders
> Arthritis/rheumatic disorders
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CATAFLAM |
| Manufacturer |
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Novartis Pharmaceuticals Corp |
| Legal Classification |
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Rx
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| Pharmacological Class |
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NSAID (benzeneacetic acid deriv.). |
| Generic Name |
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Diclofenac potassium 50mg; tabs. |
| Indications |
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Osteoarthritis. Rheumatoid arthritis. Ankylosing spondylitis. |
| Children |
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Not recommended. |
| Adults |
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Osteoarthritis: 50mg 2–3 times daily. Rheumatoid arthritis: 50mg 3–4 times daily. Ankylosing spondylitis: 25mg 4 times daily, may add 25mg at bedtime. |
| Contraindications |
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Aspirin allergy. Late pregnancy. Coronary artery bypass graft surgery. |
| Precautions |
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Advanced renal disease: not recommended. Peptic ulcer. GI bleeding. Monitor AST/ALT within 4 weeks and then periodically; also blood, hepatic, and renal function in chronic use. Edema. Cardiac failure. Hypertension. Hepatic porphyria. Elderly. Debilitated. Pregnancy (Cat.C). Nursing mothers: not recommended. |
| Interactions |
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Digoxin, methotrexate, cyclosporine, lithium toxicity. Antagonizes diuretics. May increase serum potassium level with K+-sparing diuretics. Avoid aspirin. Monitor oral anticoagulants, insulin and sulfonylureas. Increased risk of GI bleed with alcohol. |
| Adverse Reactions |
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Peptic ulcer, GI bleeding, elevated AST/ALT, abdominal discomfort, constipation, diarrhea, indigestion, nausea, abdominal distention, headache, dizziness, fluid retention, rash (discontinue if occurs), pruritus, tinnitus. See literature re: risk of cardiovascular events. |
| How Supplied |
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Tabs—100 |
| Additional Resources |
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• Related Prescribing Note |
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